Because vitamin K interferes with the effect of anticoagulant drugs (like Coumadin), the concurrent use of these agents should be avoided. 5-methyltetrahydrofolate supplementation is not recommended concurrently with methotrexate cancer therapy because they can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. Therefore, an individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate. Curcumin has been shown to reduce the therapeutic efficacy of cyclophosphamide (Cytoxan) in animal studies. In vitro research reveals that curcumin decreases camptothecin-induced death of cultured breast cancer cells. Curcumin might also interfere with the absorption and efficacy of the chemotherapy drug irinotecan, used to treat colon cancer. The concurrent use of curcumin with these agents should be avoided.

Food supplements should not be used as a substitute for a varied diet. Do not exceed the stated dosage. Store in a cool, dry place, protected from light and heat. Keep out of sight and reach of children.